The strategy covers 14 countries. Eight of them are EU members -- Austria, Bulgaria, the Czech Republic, Germany, Hungary, Romania, Slovakia and Slovenia, and six are nonmembers -- Croatia, Bosnia and Herzegovina, Serbia, Moldova, Montenegro and Ukraine.
The Danube region is inhabited by 115 million people.
Orban held a press conference with European Council President Herman Van Rompuy and European Commission President Jose Manuel Barroso at the end of a two-day summit, the Hungarian news agency said.
"The Danube region has been ridden by conflicts many times during history," Orban was quoted as saying. With the help of broader cooperation involving a macro region, conditions will be created for long-term development, he added.