Mesic will arrive in Dublin late on Tuesday afternoon after which he will meet his Irish counterpart Mary McAleese.
Mesic will then visit the Croatian Embassy in Dublin and hold talks with embassy officials and representatives of the Croat community in Ireland. He is also scheduled to briefly address the press.
On the second day of his visit, the Croatian head of state will visit the oldest Irish university, the Trinity College, founded in 1592.
Mesic will end his visit to Ireland by talks with Irish Prime Minister Berti Ahner.