The three politicians were injured but in stable condition. They are recovering at a hospital in Pristina.
The three men, Sabri Krasniqi and Daut and Artan Gashi, are members of the Democratic Alliance of Kosovo (DSK). The car exploded while en route on the Pristina-Prizren road near Lipljani.
Police suspect the blast was an attack, but have no information about the motives or the perpetrators as yet.
The DSK issued a statement labelling the incident a criminal act and demanded a full investigation.