The number of active cases rises to 961, the head of the Croatian Institute of Public Health (HZJZ), Krunoslav Capak told a news conference in Zagreb.
This is the second day in a row with record high daily numbers of new cases. On Thursday, the team reported 180 new infections.
Currently, 106 COVID patients are receiving hospital treatment, and of them 10 are placed on ventilators.
The latest two fatalities were a patient born in 1960 and a patient born in 1934 with underlying health conditions.
Since 25 February when the country reported its first confirmed case of this communicable disease, 6,258 have tested positive, and of them 163 have died, while 5134 have recovered.
Currently, 3,158 people in Croatia are self-isolating.
Since the outbreak of the disease, 134,742 people have been tested, including 1,249 in the last 24 hours.
The average age of the newly-infected patients is 31 and they usually develop mild symptoms, Capak said.